2026
Radical enzymatic peptide cyclization in natural product biosynthesis
Yao Z, Morinaka BI
2025
Peptide Recognition and Mechanism of the Radical S-Adenosyl-l-methionine Multiple Cyclophane Synthase ChlB
Ruel J, Nguyen TQN, Morishita Y, Usclat A, Martin L, Amara P, Kieffer-Jaquinod S, Stefanoiu MC, de la Mora E, Morinaka BI, Nicolet Y
Genome mining and in vivo characterization of triceptides
Yeo AYJ, Morinaka BI
2024
Antibiotics that kill Gram-negative bacteria by restructuring the outer membrane protein BamA
Modaresi SM, Sugiyama R, Tram NDT, Jakob RP, Phan CS, Saei AA, Morishita Y, Mühlethaler T, Lim J, Ritz D, Long PSY, Lehner PA, Lim ZH, Degen M, Yao Z, Maier T, Hou Y, Lee JY, Xu J, Yeat AYJ, Koh KTS, Goh WY, Ling SYH, Chua PWL, Yamazaki M, Ee PLR, Hiller S, Morinaka BI
Fused radical SAM and αKG-HExxH domain proteins contain a distinct structural fold and catalyse cyclophane formation and β-hydroxylation
Morishita Y, Ma S, De La Mora E, Li H, Chen H, Ji X, Usclat A, Amara P, Sugiyama R, Tooh YW, Gunawan G, Pérard J, Nicolet Y, Zhang Q, Morinaka BI.
Accessing and exploring the unusual chemistry by radical SAM-RiPP enzymes
Guo Q, Morinaka BI.
The Triceptide Maturase OscB Catalyzes Uniform Cyclophane Topology and Accepts Diverse Gly-Rich Precursor Peptides
Purushothaman M, Chang L, Zhong RJ, Morinaka BI.
Substrate Promiscuity of the Triceptide Maturase XncB Leads to Incorporation of Various Amino Acids and Detection of Oxygenated Products
Phan CS, Chang L, Nguyen TQN, Suarez AFL, Ho XH, Chen H, Koh IYF, Morinaka BI.
Functional and Promiscuity Studies of Three-Residue Cyclophane Forming Enzymes Show Nonnative C–C Cross-Linked Products and Leader-Dependent Cyclization
Suarez AFL, Nguyen TQN, Chang L, Tooh YW, Yong RHS, Leow LC, Koh IYF, Chen H, Koh JWH, Selvanayagam A, Lim V, Tan YE, Agatha I, Winnerdy FR, Morinaka BI.
2022
The Biosynthetic Landscape of Triceptides Reveals Radical SAM Enzymes That Catalyze Cyclophane Formation on Tyr- and His-Containing Motifs
Sugiyama R, Suarez AFL, Morishita Y, Nguyen TQN, Tooh YW, Roslan MNHB, Lo Choy J, Su Q, Goh WY, Gunawan GA, Wong FT, Morinaka BI.
2021
Genome-Mining-Based Discovery of the Cyclic Peptide Tolypamide and TolF, a Ser/Thr Forward O-Prenyltransferase
Purushothaman M, Sarkar S, Morita M, Gugger M, Schmidt EW, Morinaka BI.
2020
Post-translational formation of strained cyclophanes in bacteria
Nguyen TQN, Tooh YW, Sugiyama R, Nguyen TPD, Purushothaman M, Leow LC, Hanif K, Yong RHS, Agatha I, Winnerdy FR, Gugger M, Phan AT, Morinaka BI.